1. Meredith Grey (Missy Goldberg)

2. Sean Penn (Eric)

3. Dakota Fanning (Mackenzie)

4. Brad Pitt (Will)

5. Julia Roberts (Susie Moss)

6. Jeff Goldblum (Leonard Hayes)

7. Brooke Shields (Erika Ford)

8. Helen Hunt (Jamie Buchman)

9. Rebecca Romijn (Cheryl)

10. Freddie Prinze Jr. (Sandy)

11. Charlie Sheen (Ryan)

12. Ben Stiller (Tommy)

13. Gary Oldman (Richard Crosby)

14. Alec Baldwin (Parker)

15. Selma Blair (Wendy)

16. Bruce Willis (Paul)

17. Reese Witherspoon (Jill Green)

18. Susan Sarandon (Cecilia Monroe)

19. Christina Applegate (Amy Green)

20. George Clooney (Dr. Doug Ross)

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